Whole-body hyperthermia treatment can improve thermoregulation in depressed individuals by sensitizing thermal regulatory cooling pathways.

“So in the European study, we actually very successfully measured core body temperature the day before they got to treatment, and five days after. What we found was that the hotter you were before you got into the box, the better antidepressant response you got. What we found from five days after being in the box, everybody’s core body temperature was really lower over 24 hours. So the box didn’t make people hotter, it made them cooler. What we were actually inducing was hypothermia. We used hyperthermia to induce hypothermia.”