The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's one of the only natural compounds that may inhibit myostatin too so it has that upside um and it's like all the things it does from a neurological standpoint perhaps fertility it's even used for depression now in women at like 10 plus grams or something which is crazy
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I've been recommending this to patients for 6 months now. The big shift is patients actually do it because the explanation is concrete.
Same in nutrition counseling. The before/after framing helps.
Tracking with a CGM on top of this for 3 months. Variability dropped quickly and stayed dropped.
Worth noting the 0.71 SMD in the Kreider meta is in trained athletes. Effect in untrained adults runs closer to 0.3 — still meaningful, but the panel should reflect that gradient.
Good catch. Could the brief surface the training-status interaction inline?
it's, like, all, the, things, it, does from, a, neurological, standpoint, perhaps fertility, it's, even, used, for, depression now, in, women, at, like, 10, plus, grams, or something
there's some I think rather weak data that suggest that um it help it may help reduce dementia uh pardon me it help reduce depression in women um and there's some evidence to suggest that it may be helpful during periods of you know sort of Rapid hormonal change um and that could be sort of within the monthly period of um a menstrual cycle um pregnancy per menopause and menopause
My guess is that NMN works through the same NAD+ pathway as NR but more research is needed.
Can creatine help with depression and anxiety?
so there's been some interesting research with creatine and depression yes there has it's an emerging area primarily to Utah there a great Psychiatry group there and uh as a cavea no study has ever looked at creatine without anti-depressant medication so they're always as adjunct so we're not creatin could ever replace anxiety or anti-depressive medications but in these sub populations primarily females with clinical depression it's really starting to have some um speed up recovery and decrease some of the symptoms
5 g of creatine monohydrate daily improves muscle strength and lean mass in healthy adults at standard training loads.
Creatine improves cognitive performance, especially under sleep deprivation and high cognitive load.
Creatine improves cardiovascular health markers and reduces all-cause mortality risk.
Creatine supports bone-mineral density in post-menopausal women when paired with resistance training.
Women need higher creatine doses (8–10 g/day) than men to reach the same intramuscular saturation.