I have found for me that I feel best when I supplement with creatine which eases the demand on the methylation cycle and I get enough riboflavin as I mentioned earlier if you're getting enough riboflavin probably two plus milligrams a day is adquate for most people and you're only going to get that from heart and liver in the food Kingdom or a direct riboflavin supplement the MTHFR enzyme works like normal even with polymorphisms including the 677 C Tot polymorphism