Creatine synthesis is designed to fluctuate with methyl group availability, allowing for synthesis when methyl donors are abundant and reduced synthesis during fasting.

“so taking a small amount of creatine per day May benefit you in terms of easing the body's work to methylate”

“so taking a small amount of creatine per day may benefit you in terms of easing the body's work to methylate”

“supplementation with creatine makes a lot of sense because 45% of your methyl demand is to synthesize creatine”

“creatine is the ideal thing to vary with the methyl group supply because you can eat a steak you can do all your creatine synthesis when you were when you had enough methyl groups then 5 hours later you're in the fasted State and you you don't synthesize creatine anymore it doesn't matter”

“creatine is the ideal thing to vary with the methyl group supply because you can eat a steak you can do all your creatine synthesis when you were when you had enough methyl groups then 5 hours later you're in the fasted State and you you don't synthesize creatine anymore it doesn't matter because it's not a neurotransmitter it's not doing an acute thing you just have to make sure that in 60 days from now your creatine isn't zero it's still 120 grams in your body”