Inhibiting COX-1, COX-2, and 5-lipoxygenase enzymes with curcuminoids or ibuprofen leads to downstream consequences.

“physiologically if you inhibit the cox 1 and cox 2 enzymes and the 5 like oxygenase enzymes in your human body whether it's with a curcuminoid from turmeric or ibuprofen as a molecule you will suffer downstream consequences”