Cortisol is converted to cortisone when a person is taking glucocorticoids, has hyperthyroidism, progesterone, PCOS, or is taking supplements like curcumin.

“the direction of travel is determined by various things so cortisone gets converted to cortisol preferentially when you have insulin resistance obesity inflammation low thyroid function leptin resistance the other direction cortisol being turned into cortisone is uh facilitated when you have glucocorticoids so for example if a patient is taking steroids understandably the body says we don't need any more cortisol let's turn it into cortisone hyperthyroidism progesterone PCOS and even supplements like curcumin”