Blood-brain barrier leakiness increases in the hippocampus and medial temporal lobe with normal aging.

“what we've noticed is when we scan normal in cognitively normal individuals young and old just normal aging we start seeing some brain regions that are leakier than others so first of all there's what we call the blood brain barrier there's not only one blood brain barrier in my opinion there's several and we are trying to understand how they have different properties different depending on where we look in the brain but we see special brain regions that starts to leak with normal aging and these regions it's a bit um does the the region of the Epic campus with that we called medjool temporal lobe”