Leigh syndrome is a clinical syndrome caused by mutations in approximately 80 genes, leading to subacute degeneration of gray matter and rapid neurodegeneration.

“one of the clinical syndromes that we study something called lis syndrome so there's about 80 different genes that can be mutated to give rise to this clinical syndrome which is basically a subacute degeneration of the gray matter it's a very rapid neuro degeneration it's a terrible terrible disease”