Tryptophan levels in the brain are maintained during chronic inflammation, suggesting active transport into the CNS to maintain serotonin levels.

“So there’s a, I can’t remember the name of it, but there’s, it’s an amino acid pump, it’s got a fancy name, that basically actively transports amino acids. So although we never really followed up on this, the suggestion is that when you’re under chronic inflammation or some sort of, what’s the word I wanna use, accommodation that’s made so that your tryptophan, you preferentially shunt tryptophan into the central nervous system, probably because you’ve got to have serotonin in there.”