Fructose causes fatty liver and metabolic syndrome in mice even without causing weight gain when food intake is controlled.

“high fructose corn syrup prompts considerably more weight gain than sucrose you can see here rats with access to high fructose corn syrup gain significantly more weight than those with access to table sugar even when their overall caloric intake was the same”

“and this is not the same as regular sucrose both in animal studies and in humans as I mentioned not a huge fan of pure sucrose and humans they're much better ways to get your carbohydrates”

“in pear feeding we give each animal eats the same amount of food so if you give one animal sugar which normally makes it want to eat more because it causes this thing called leptin resistance where they want to eat more but if we don't give them any more food we only give them the same amount as the control then there will be no difference in weight but there will be differences in fatty liver metabolic syndrome and so forth”

“with soft drinks really was all fructose even though there's a lot of glucose in there we saw a little bit of weight gain with glucose alone but when we give high fructose corn syrup we it was pretty much all from the fructose that was causing them to gain weight and to get metabolic syndrome”

“we actually did another study at peter where we gave soft drinks a high fructose corn syrup to to animals and they got really fat and insulin resistant but if we blocked fructokinase we completely blocked the development of metabox syndrome”

“i believe rick johnson described an experiment like that on my recent podcast with him which was an iso caloric swap to a very high fructose diet where the animals didn't gain weight but they fueled partitioned differently they got fatter this was over a long time this was over nine months”