ATP depletion from fructose metabolism leads to a fall in intracellular phosphate, activating AMP deaminase.

“and the reason that phosphate falls is because it's taken up in the fructose-1-phosphate or it's taken up by fructose so the fructose gets phosphorylated by the atp and it becomes fructose-1-phosphate that sequesters phosphate and there is this process where both atp levels fall and intracellular phosphate falls and that triggers this ampd pathway”

“yeah so the atp depletion triggers a series of reactions and what happens what the key one is not only does atp decrease in the cell but intracellular phosphate also falls and that activates an enzyme called amp deaminase that converts the broken down product of atp which is amp and it converts it to uric acid”

“and that amp is removed by an enzyme called deaminase which turns out to be a very very important enzyme in this pathway and that can breaks down the amp stepwise until it produces uric acid”