Activation of the polyol pathway and increased aldose reductase expression in the liver can lead to greater weight gain from high glycemic foods as people age.

“what happens is when you're young and you don't have this polyol enzyme pathway activated eating things like potatoes and french fries may not cause so much weight gain you you may feel you're invincible but as this pathway gets activated and aldo's reductase starts being highly expressed in the liver then potatoes and bread may cause much more weight gain”