Uric acid causes oxidative stress to mitochondria, inhibiting the Krebs cycle and leading to increased fat production.

“and the uric acid inside the cell actually causes oxidative stress to the mitochondria and the mitochondria are also a really important in atp production and the oxidative stress causes affects the several ways first it um i don't know if you want to go into all the biochemistry or not no let's do it we're going to bring it back and summarize it but let's let's keep going deep so it inhibits an enzyme called econotase which is involved in the krebs cycle and it basically leads to citrate accumulation in the stimulation of fat production”