Peter Attia· MD
so the uric acid concentration in the blood is a proxy for total fructose consumption now there are other things that make uric acid go up too like protein but all things being equal they do correlate with each other
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so the uric acid concentration in the blood is a proxy for total fructose consumption now there are other things that make uric acid go up too like protein but all things being equal they do correlate with each other
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what we do have are some indirect measures of fructose shall we say bio toxicity yeah like uric acid or alt would be exactly those are the ones I was going to bring up exactly
we've shown that serum uric acid in children and adolescents correlate with sugar beverage consumption for instance and other people have shown that that uric acid matters because uric acid is the inhibitor of endothelial nitric oxide synthase that's an enzyme that exists in your vascular tree that vaso dilates the blood vessels and that keeps your blood pressure down and we have shown that every increase by 10% in fructose consumption increases your blood pressure by two millimeters of mercury consistently