Enzymes that add or remove methyl groups, such as DNA methyltransferases and TET enzymes, are being investigated for their role in regulating epigenetic age, and mutations in these enzymes can significantly affect epigenetic age.

“so the question is there's a group of d-methylases that can take off the methyl group that become active and take it off of this gene and um they're active by imp they're activated by inflammation so what i'm wondering is is anyone looking at obviously these methyl groups are changing and so the enzymes that are pulling off methyl groups and the d-methylases the enzymes that are putting them on their methyl transverses yes they must be doing something yeah yes and people are looking at it yeah i mean what's changing those enzymes like is there a signal there or is it a gene is it genetic control or what is it yes you know that can change yeah um you make very good points so if you want to understand the epigenetic clock clearly you start with so-called dna methyl transfer raises or these tet enzymes why because they on the one hand add methyl groups or remove methyl groups so that's a low hanging fruit and just recently we and others several groups have actually found no doubt these when you interfere with these enzymes you affect epigenetic age they're very exciting findings where people studied certain developmental disorders where where mutations deactivated dna methyl methyl transfer rays or mutation rendered it overactive you know and sure enough all of these mutations in humans you know affect epigenetic age and so at that level we know it has an effect as expected and the effect is pronounced it could add fi it could add five or ten years to a person or or the opposite you know”