Restoring the epigenome to a youthful state may re-establish homeostatic mechanisms that maintain cellular health and repair damage.

“maybe one way to think about it is you restore the homeostatic mechanisms to a more youthful state where then the homeostatic mechanisms that all of our cells have can basically clean up the rest of the mess right because we know as we get older for example we all accumulate damaged mitochondria changing the epigenome which is the nuclear genome isn't going to fix anything that's wrong with your mitochondria directly but maybe by fixing the epigenome you restore the homeostatic mechanisms that then maintain mitochondria in a healthy state and you can fix the damage to the mitochondria”