Epigenetic clocks track something central to development, as many involved genes are developmental genes.

“all the processes that play a role in development must be must be playing a role here and the reason is because um the my original pan tissue epigenetic clocks works actually beautiful in prenatal brain samples it works beautifully in in various in vitro studies of so-called three-dimensional brains you know or in or in retina samples so really it captures aging of gestational age during development you know and that and during development there's really no noise you know this is a highly coordinated process and so so yes these processes also must play a role you know”