Paul Saladino· MD
beta-hydroxybutyrate itself has epigenetic roles like i mentioned earlier it's an hdac one inhibitor so histone the acetylase inhibitor as well and it can affect foxo3 and potentially nam pt
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
beta-hydroxybutyrate itself has epigenetic roles like i mentioned earlier it's an hdac one inhibitor so histone the acetylase inhibitor as well and it can affect foxo3 and potentially nam pt
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So, there’s another link there that, you know, brings not only the pentose phosphate, NADPH, but beta-hydroxybutyrate actually protects against oxidative stress, both as a nutrient, but also as a transcription or regulator.