Estrogen can be beneficial in younger animal models by reducing stroke size when administered after ovariectomy, but it can worsen stroke outcomes in older animals.

“the other part of that is that the way to show effect of estrogen in animal models was to take their ovaries out and give them estrogen and then you could show you could do lots of provocation it was good so estrogen is a good hormone on a young body but then there were studies that were hardly published but I was aware of them of taking all the animal you know so you could take the young animals in just one Center in Houston they did it you took the young animal you took their ovaries out you gave them a sturgeon and you employed a stroke model okay and when you give estrogen the stroke was smaller and everything when you did the same in older animals the stroke became worse”