The molecular mechanisms by which estrogen and progesterone withdrawal increase cancer risk are not fully understood, but the strategy is to alter the cellular environment to make it less conducive to cancer growth.

“the best answer I can give is we think we understand the environment that is friendly to a cancer which is the environment in which the cancer develops and we try to change that environment to make it less conducive to the continued growth of the cancer that means in a low estrogen environment you might use estrogen because that is now unfriendly to the cancer in a high estrogen environment you might remove estrogen same with testosterone but exactly how that works I would use a lot of fancy words and they would try to cover my ignorance”