Peter Attia· MD
The increased risk of breast cancer seen with estrogen plus progestin was mostly be attributable if not entirely attributable to the progesterone to the medroxy progesterone acetate
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The increased risk of breast cancer seen with estrogen plus progestin was mostly be attributable if not entirely attributable to the progesterone to the medroxy progesterone acetate
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the most surprising finding in terms of breast cancer was that no increased risk of breast cancer was seen with estrogen alone even though the observational studies had suggested that both estrogen plus progestin and estrogen alone would be associated with increased risk of breast cancer
nothing about this study suggested that estrogen is causing breast cancer if anything this study suggested MPA is causing breast cancer based on the fact the group that was only receiving estrogen had a reduction in the incidence of breast cancer while the group that received estrogen plus MPA is the group that saw this small potentially statistically significant but potentially clinically insignificant increase
estrogen absolutely did not drive either the incidence of breast cancer or mortality associated with breast cancer and again that was not true in 2002 it was not true in 2006 it is not true today