The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
although there was this increase 25 30 percent increase in risk of breast cancer seen with estrogen plus progestin there was no increase in breast cancer seen with estrogen alone and would longer follow-up there was the emergence of a reduction in breast cancer close to a 20 reduction seen with the conjugated estrogen
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probably the most prudent and cautious approach is to assume that at least with longer duration of treatment with estrogen plus progestin there will be an increased risk of breast cancer
there was an expectation that there would be at least a modest increase in risk of breast cancer with giving either estrogen plus progestin or estrogen alone
the increase in breast density was greater with estrogen plus progestin than with estrogen alone
there was an increased risk of breast cancer with estrogen plus progestin also there were denser breasts developing over time
the absolute risk difference was a difference of five women per thousand to Four Women per thousand so as you went from four cases of breast cancer per thousand women to five cases of breast cancer per thousand women that is indeed an increase of 25 5 minus four is one divided by 4 is 0.25 but what's the absolute risk reduction or in this case risk increase it's one over a thousand or zero point one percent
it got reported that the women receiving the hormone replacement therapy had a 25 increase in breast cancer and that was true at a relative risk level
Women who were on the estrogen alone, so they didn't have a uterus, so they didn't need the progesterine therapy, had a decreased risk of getting and dying from breast cancer, right?
women who were on the estrogen alone, so they didn't have a uterus, so they didn't need the progesterine therapy, had a decreased risk of getting and dying from breast cancer, right?
We figured out pretty quickly how to combat that. If you just oppose the estrogen with progesterone, you keep the endometrial lining in check.
When you took estrogen and progesterine or estrogen alone, you had a decreased risk of colon cancer. You had decreased risk of fractures, like significant decrease of fractures, decrease of diabetes. We saw a decrease in overall mortality, a decrease in cancer specific mortality.
When you took estrogen and progesterine or estrogen alone, you had a decreased risk of colon cancer. You had decreased risk of fractures like significant decrease of fractures, decrease of diabetes. We saw a decrease in overall mortality, a decrease in cancer specific mortality.