what we observe is that there are transcriptional programs with multiple inputs some of which we discussed earlier but those are probably not that will basically turn on all 1000 of those proteins to produce more mitochondria but that same program is also saying hey let's turn over some of the previously produced mitochondria so it's a very very smart system it's not gonna just produce more good mitochondria in the presence of bad mite as it'll actually cleanse the system as well