Exercise lowers IGF-1 in the bloodstream by redirecting it to muscles and the brain, and increases IGF-1 receptor density in muscle cells.

“exercise actually causes igf-1 to go into muscle where you're repairing damaged muscle it's helping muscle repair it goes into your brain it's important for like neurogenesis”

“And I know that it's been shown in humans that IGF, yeah, it's been shown in humans that acute exercise, I think it was aerobic, lowers serum IGF-1.”

“So the exercise sort of primes that IGF-1 that's released downstream of growth hormone from the sauna to go into the brain, where it plays a role in actually helping BDNF, brain-derived neurotrophic factor, in growing your neurons.”

“exercise lowers igf-1 in the bloodstream redirecting it to where it can be beneficial like the muscle and notably the brain here's why that's important when you exercise whether it's cardiovascular exercise or strength training or high-intensity interval training it stimulates muscle fibers and increases igf-1 receptor density in the muscle cells”

“Exercise positively influen uences how the body uses amino acids, and growth factors like igf-1 and proteins like mtor directing them towards the muscle and brain health where they're most beneficial”