this exacerbation of symptoms we have to work around the side effects and the symptoms that patients are experiencing to make sure the exercise is safe and tolerable for them so you know if patients are experiencing peripheral neuropathy um some patients experience issues with a taxia balance and stuff as well so you know we're putting patients on treadmills we have to be careful that um they're going to be able to do that type of exercise and then side effects like like I say like diarrhea skin irritation