Rhonda Patrick· PhD
High-intensity but not low-intensity exercise increases serotonin.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
High-intensity but not low-intensity exercise increases serotonin.
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There is a linear association between exercise intensity and plasma 5HT - with high intensity being the most robust.
So there have been human studies that have found that they've looked at dose dependent in terms of exercise, moderate, light, moderate and vigorous intensity exercise. And they looked at serotonin levels and the more vigorous intensity the exercise, the higher the serotonin levels are.