Paul Saladino· MD
it's also the decrease in oxygen concentration the partial pressure of oxygen that's that's produced locally which stimulates something called if one alpha which is hypoxic inducible factor and so this veg F is just great
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's also the decrease in oxygen concentration the partial pressure of oxygen that's that's produced locally which stimulates something called if one alpha which is hypoxic inducible factor and so this veg F is just great
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one of them are transcription factors and hypoxia inducible factor hi1 hif alpha is one example of a transcription factor that is known to be operate upregulated in the context of hypoxia and now our cells and other groups have reported some upregulation that is the context of exercise
the idea of a stressor right so the idea of this sort of disconnect between what the neuron is doing in terms of activity and the metabolic demand it itself may be driving transcription factor changes that then may upregulate metabolism or alterations in lactate uh transport as an example right and that's uh some of the interests that we have right now which may be metabolically driven