Peter Attia· MD
we think again that these two things are some of the more major regulators of mechanotransduction um in terms of how muscle actually gets built
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we think again that these two things are some of the more major regulators of mechanotransduction um in terms of how muscle actually gets built
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the z disk is where something called phosphatic acid is stored and if you were going to try to transfer a mechanical signal to a chemical signal it makes sense that you would store this stuff in the z disk because that is where a lot of that mechanical tension is going to be felt so in response to that mechanical tension again based on mechanistic studies we believe what happens is that causes phosphatic acid to be released and phosphatic acid is a stimulator of mtor