Vigorous intensity exercise has anti-cancer effects independent of the immune system by mechanically killing circulating tumor cells through blood flow shear forces.

“The shear force of blood flow generated during vigorous-intensity exercise kills circulating tumor cells”

“Well, these circulating tumor cells escape the primary tumor site. They get into circulation and then they go elsewhere and then establish camp there, right? So the metastasis process. Well, exercise itself, there's something called sheer force. The sheer force of blood flow going through the circulatory system itself kills these circulating tumor cells. And it does it because these tumor cells have these mechanoreceptors on their cell surface. And they're so sensitive to movement. It's almost like a hurricane. It's like a hurricane just coming through and just wiping it out. And so there's been studies showing that the people that have been diagnosed with either colon cancer or breast cancer, when they engage in physical activity, aerobic exercise, they are circulating tumor cells drop down. They're less likely to have cancer recurrence, I mean, dramatically in some cases. You're talking like 40% and they're less likely to die from their cancer.”

“just the mechanical force of blood flow blood flow actually affects what are called circulating tumor cells so circulating tumor cells escape from the primary side of the tumor get into circulation eventually travel to distant sites and then they take residence and establish a new tumor elsewhere so this is the metastasis um so circulating tumor cells you obviously uh do not want to have them in circulation because they can uh play a role in metastasis well the shearing forces of blood flow itself can kill these circul circulating tumor cells because on every cell surface we have a mechanical um we have these mechan mechano receptors that respond to movement and cancer cells are all wonky and disrupted and messed up and so they just can't handle that movement and they die”

“through the shearing forces of your blood just blood flow so just getting that blood flow to go faster by exercising by getting that exercise — kills what are called circulating tumor cells”

“aerobic exercise in particular anything that's really increasing blood flow does seem to really have an effect on these circulating you know tumor cells then it would seem silly for someone who is has been diagnosed has been treated for cancer to not be just moving like their life dependent on it right exercising as much as possible because it seems like that would be your best bet for uh reducing the cancer metastasis and and ensuring that these circulating tumor cells do not go and take Camp into another organ”

“yeah based on the mechanism then anything that increases that blood flow should work so some of the research that's been done done has been more of a preclinical invitro model so there's researchers who developed these plastic tubes uh rubber kind of tubes and they can spin blood through these tubes faster or slower and then they can put these circulating tumor cells in these this sort of microfluidic system that they've developed and they can spin them around faster and slower and they show that the faster you spin these around consistent with what might happen during exercise the more of these cells that die so they've not looked at what's causing that increase um in blood uh uh hemodynamic sheer stress so yeah in theory both strength training and aerobic exercise should be able to do it”

“those circulating tumor cells are less likely to survive because of the increased sheer stress so when blood's flowing through uh uh the vascul it's under a certain amount of pressure but of course that's dramatic increased when you exercise and these circulating tumor cells are far more likely to die and not survive that Journey if you're exercising”