Dr. Mattson advises exercise, intermittent fasting, intellectual engagement, and a good diet for longevity due to insufficient data for other interventions like nicotinamide riboside or rapamycin.

“So, you know, my advice is to stick with exercise. I think intermittent fasting can be helpful for a lot of people. Keeping your mind intellectually engaged, eating good diet. There's just not sufficient data to support the use of any of these things, you know, whether it's nicotinamide riboside, or rapamycin seems like it's something that in animal studies looks pretty interesting, but I've been kind of hesitant to take rapamycin myself, just given that what it's prescribed for is suppressing the immune system. And long-term in humans, we don't know.”