Paul Saladino· MD
this is a guy who a 27 year old male who literally fasted under medical supervision for 382 days
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
this is a guy who a 27 year old male who literally fasted under medical supervision for 382 days
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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So, we lose that. We go to this extreme and say, "You know, look, the longest medically-supervised water fast was 382 days." And that 382 days, yeah, 382...276 pounds, 382 days, I'll send you the paper.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.