A larger last meal during a period of no food intake may lead to a greater response over a longer period, potentially balancing out the effects of time-restricted eating.

“Do they still have the same benefits or are they losing because it's like the time-restricted eating window has kind of shifted to later and obviously there is a light/darkness component to all this to some degree?”

“For example if you take an animal that is, you know, for example, nocturnal, like a rodent, a mouse, which usually eats at night, you force it to now not eat at night but to be awake during the day and eat at day and not eat at night. So if you can shift them to not eat all day, all night, but eat just within a time-restricted eating window, do we know if they eventually adjust, how long it takes for them to adjust? Does their metabolism adjust? Does their circadian rhythm adjust?”

“if you have a period to where there's less uh or there's no food intake but you had a greater meal as the last one that actually also had a greater response over a more long period of time just like the 100 gam study so it's possibly that that evens it out”