Observational studies in rodents showing health benefits from caloric restriction or reduced food intake may be misleading because the control groups are often unhealthy or overconsuming.

“I like the the the the U the discussions of course of hypercaloric diets and overeating and undereating in the light of animal experiments I mean we know that a lot of times when you have rodents in a cage and you give them at Litin Foods they actually overc consume I mean we would do the same thing if you're actually sitting in a room and they're bring you constant just warm crossant and everything you're going to overeat so the animals do that as well and then they give them a hypercaloric diet or they eat they give them less food and then they're healthier that's not necessarily that the hypercaloric diet was actually making them healthy it is that the control trial is actually unhealthy and we are that control trial”