Metformin and rapamycin mimic fasting by reducing mTOR activity and/or increasing AMPK activity.

“anything that mimics fasting the first thing that comes to mind would be metformin rapamycin things like that that what we talked about earlier just for the listener to sort of tie this together we talked about these huge pathways that tell the body nutrients are scarce so when mTOR activity is down that's a sign that we're deficient in amino acids but we can also do that with rapamycin when AMPK is up that's the cell being told we're deficient in ATP another way you can do that is to give metformin”