In a 40-day fasted state, subjects exhibit high free fatty acids, low insulin, low glucose, and high ketones, potentially appearing insulin resistant short-term but becoming insulin sensitive after refeeding.

“you know when you look at Cahill's 40-day fasted subjects they're free fatty acids were through the roof their insulin was very low their glucose was very low their ketones were very high it's interesting to know would you call them insulin sensitive or insulin resistant right because probably if you challenge them with glucose immediately they would have hyperglycemia physiologically their muscles probably would in the in the short moment say hey I don't want this stuff safe every gram of that for the brain but presumably if Yuri fed them carbs for three days they'd probably be as insulin sensitive as they'd ever been right”