A short period of caloric restriction (e.g., two to three days) can produce significant survival benefits, comparable to lifelong caloric restriction.

“suggesting that just that period of caloric restriction could produce a similar benefit now I could be a little wrong on the numbers but that was sort of the gist of my memory is that correct yeah well what he did the it actually cut off blood supply of the kidneys yeah another one that they did the liver okay same result though and you're exactly right they did these ones that have been calorically restricted their whole lives the ones that have been that were ad-lib and then the ones that have been fasted for they did some that have been fast uh restricted for a few weeks and then some that had been just fasted water only fast for a day two or three days that's a big thing it is a big fact that's absolutely right and they did much better you're right I don't remember if all of the controls die but if not almost all of them did and and and the ones that were restricted lifetime or for two or three days I think none of them died so you're right it's yeah when I said a surgery I guess I was thinking about it from a mouse ologist's standpoint where a lot of our surgeries don't turn out so well but yeah this this wasn't a minor uh surgery that you expected everybody literally we're expecting most of the mice were gonna die and they and they did so yeah I mean I that that kind of I think it changed my thinking entirely uh about about dietary restriction and you're right we use these in different terms initially it was called dietary restriction because they just restricted the amount of diet but then after they decided it was calories that counted then they started being called calorie restriction and now probably not exactly calories so I don't know food restriction maybe we should call what they do to them to the mice at this point”