Rhonda Patrick· PhD
That's why, as you pointed out, clearly mitochondria might be playing a role, and in fact, in liver we do see increase mitochondria volume, and increase endoplasmic reticulum volume, so ER and mitochondria kind of work together. That's what we are learning these days. So the mitochondria volume increases. Another thing is we do see less damaged mitochondria in liver when they eat only from eight to nine hours. Second thing is this mitochondrial effect is not restricted only to liver. We do see increased mitochondrial volume in brown adipose tissue, so in brown fat. As you know, these mitochondria have kind of dissipate until they are literally burning the fat. So, at least in two different organs, we have seen increased mitochondrial volume. That correlates with increased level of PGC-1alpha that's involved in mitochondria biogenesis.