Paul Saladino· MD
when you're in ketosis or fasting your nad nadh ratio changes positively and you turn on sirtuin genes
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when you're in ketosis or fasting your nad nadh ratio changes positively and you turn on sirtuin genes
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And SIRT1 gets activated every time you're making... So, when you're eating anything when you're eating food, you're going to make NADH, which is which is going to shut off SIRT1, which is also part of the benefit of fasting.
when cellular energy levels are low such as during exercising fasting or Cal work restriction nad levels rise which also means the ratio of nad to its reduced form NADH increases and this serves as a sensor to switch on soar to an expression in subsequent activity
nad levels are heavily influenced by lifestyle and particularly things that cause energy stress like fasting caloric restriction and exercise which all raise nad
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