Rhonda Patrick· PhD
your liver glycogen starts to deplete at, like, 10 hours of not eating
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
your liver glycogen starts to deplete at, like, 10 hours of not eating
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Whereas, you know, obviously when you're not eating for 16 hours, if you're doing a time-restricted eating schedule of eating within eight hours and you're fasting every night for 16 hours, you're in a fasted state in a way. I mean maybe it's not fasting, but, you know, you're liver glycogen starts to deplete at, like, 10 hours of not eating and, you know, something like this.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.