Peter Attia· MD
48 Hours of of fasting will usually kill a mouse
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
48 Hours of of fasting will usually kill a mouse
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Maybe you should go back and listen to the dozen times I’ve said you can’t compare humans to mice because mice lose 20% of their body weight after a 48h fast.
There's a fundamental difference between rodents and humans, and so, the two days that you have been alluding to cause a 20% weight loss in mice, that are, at this time point, at the verge of death. Another day would potentially kill them. And so, 20% is a lot, so imagine this for yourself. In two days. In four days, a human being only loses one to two percent of his or her weight.
if you fast a mouse for 48 hours, they can lose, like, up to 20% of their body weight, which is, like, phenomenal.
As you mentioned, the mice, they die, if they go beyond three days or so. They will die.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.