Cyclic fluctuations in IGF levels through fasting and refeeding may be healthier for longevity than constant caloric restriction.

“and there's part of me that just wonders if a cyclic approach to IGF is a healthier approach then say constitutively being calorically restricted and just you know because you could starve yourself of methionine and eat no protein and live at a lower IGF of maybe 110 forever but I wonder if the the real game is sort of figuring out this sort of cycle and periods of just just as we think of a toff oh gee if you're always in a state of a tofu gee that's a bad thing if you never have a tofu gee that's a bad thing”