We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
the changes in the testosterone and the igf-1 are what concern me along with the t3 we see this a lot of times in ketogenic diets and this happened to me my tsh didn't really budge but my t3 went down and my basal body temperature went down i think this is the body entering a sort of you thyroid sick state a caloric deprivation a sort of starvation survival state that i don't think is optimal for humans and we see that in the testosterone decline
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
but if you look at the results in more detail you find that testosterone and insulin-like growth factor igf-1 decreased significantly in time-restricted feeding with no changes in the control group adiponectin increased in the time-restricted feeding while the total leptin decreased although not when adjusted for the fat mass triota thyronine which is t3 decreased in the time-restricted feeding group but no changes were detected in the tsh total cholesterol hdl ldl or triglycerides resting energy expenditure was unchanged but a significant decrease in the respiratory ratio was observed in the trf group probably because they were shifting more toward fat metabolism and the rq was changing but the changes in the testosterone and the igf-1 are what concern me along with the t3
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.