The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the fact that you know all the normal cells is you're enhancing all these stress response pathways so the chemo drug becomes that much more or less almost less you know efficacious like it's like almost like a lower dose because it's like got these robust anti-apoptotic in anti stress response genes that are dealing with that sort of stress and so it's like it can take the toxic and sole because of that upregulation that fasting is doing
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and the cancer cells just can
One of the early hopeful areas of research of prolonged fasting and fasting-mimicking is a property called "differential stress resistance" where fasting may temporarily make cancer more sensitive and healthy cells less sensitive to treatments that themselves can be carcinogenic.
So, if you starve any system, virtually any system, they'll go into this shielding mode, protected mode, and then, they sit there until food comes around again. So, in this protective mode, they're very resistant to all kinds of things. They're resistant probably because they have to be resistant to the sun, and to chemical produced by other microorganisms that might be surrounding them. And so, then, they happen to also, at least in mice and now we think humans, chemotherapy is also one of the toxins that they're resistant to. So, you starve the normal cells going to the protected mode when you starve a cancer cell though because the oncogenes are the regulatory genes of this protection. The cancer cells, by definition, can never respond, right?
that largely has to do with the fact that fasting activates those stress response pathways I just mentioned that are meant to be switched on that humans because of our active 24-hour access to food these days never switch on well normal cells switch them on and so when you switch on those stress response pathways they actually become more resilient to stress like chemotherapy radiation
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.