Fructose preferentially decreases mitochondrial function, stimulates glycolysis, causes oxidative stress, and leads to inhibited fat oxidation and increased fat generation.

“in addition fructose preferentially decreases mitochondrial function and stimulates glycolysis and so all those things cause you get this big oxidative stress to the mitochondria and there's an enzyme in the mitochondria that drives fat oxidation called enolco hydratase i mean sorry to throw it out there this is what we're hearing no no we're here to talk about it but basically uh the oxidative stress inhibits that so fatty acid oxidation goes down so you block fat burning and then in addition you block an enzyme called econotase with oxidative stress to the mitochondria and that increases citrate which drives fat generation and so you end up with fatty liver that's driven by both increased fat synthesis and a blocking fat burning”