Peter Attia· MD
Donnelly showed in 2005 that de novo lipogenesis was worth about 25 percent of the fat in the liver
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Donnelly showed in 2005 that de novo lipogenesis was worth about 25 percent of the fat in the liver
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
solves the problem of the central paradox that is why is this liver cell making so much new fat from glucose because it's jammed full of fat the glucose from the outside cannot go in but the liver cell is so busy trying to make new fact an oval lipogenesis that is just shoving it out the door but there's too much going in
when you get into requiring high amounts of denimo lipogenesis now we start talking about fatty liver and so now you start seeing triglyceride problems and so people who are actually doing a lot of denovo lipogenesis typically have elevated triglycerides