Isolating specific dietary inputs or outputs for their impact on NAFLD in humans is difficult and likely requires controlled metabolic ward studies.

“are you aware of any data that have done a great job at trying disentangle those two and it doesn't necessarily be fructose but it could be an input issue so ethanol PUFA fructose an output issue choline or the way you describe it is sort of this in-between visceral thing which is visceral fat tends to decrease when adiposity decreases so it's almost like there's a third variable and it is challenging in humans to figure out how to isolate each of those I don't think you can do it in humans well I think you could do it in humans I don't think anyone will do it in humans and I don't think that there's any data out there that do do it in humans and I don't think anyone will ever bother to try to figure that out because what that would require would be putting people in a metabolic Ward and feeding them precisely controlled diets”