Targeted liver uncoupling is being explored as a treatment for metabolic diseases like NAFLD and NASH.

“so the ind has already been filed for this is it in phase one human yet no no we're still exploring pre-clinical models thinking potentially about first starting out where there are no indications for things like lipodystrophy where leptin's not working so i think my thinking is i'd like to go slowly here hopefully within the next year or two we may be in humans i think initially going after orphan diseases where there simply is no other treatment and that would be certain forms of lipodystrophy where they get very bad diabetes nafl nash and especially in conditions where leptin's not working”