Paul Saladino· MD
The MTHFR enzyme works like normal even with polymorphisms including the 677 C Tot polymorphism so for me it doesn't seem like supplementing with methylfolate or folinic acid is necessary
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The MTHFR enzyme works like normal even with polymorphisms including the 677 C Tot polymorphism so for me it doesn't seem like supplementing with methylfolate or folinic acid is necessary
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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