Low methylfolate levels can cause the body to methylate glycine and excrete it as a methyl buffer, suggesting a potential need for increased glycine intake.

“methylfolate is the thing that controls whether you pee out glycine as a methyl buffer if your methyl folate level is low I'm closing my eyes because I'm now trying to figure out how trimethylglycine will fit into this because I have an anecdote to share with you so well trimethylglycine is beatta eaten which is a thing that you make from choline finish your story I'm going to come back to this interesting anecdote because I'm I'm looking forward to explaining to me why I observed this case but keep going okay this when your methyl folate level is low your body thinks that you are in a state of methyl abundance and that you need to methylate glycine and pee out the methyl groups and the glycine into the urine and so you probably need more glycine as well”