For people unable to adhere to strict caloric restriction, pharmacological interventions like GLP-1 agonists, rapamycin, carbos, SGLT2 inhibitors, and metformin are potential alternatives to test for longevity benefits.

“if we want to ask the question how would you help the 99% of people who on their own could not adhere to that the answer of course becomes CTIC drugs right this is the question that is on everybody's mind which is Eric you've convinced me that CR to this extent will absolutely help me live a longer better life but I just can't do it you know I'm not in that percent of the population but will a GL P1 Agonist give me the same benefit will rapy give me the same benefit will a carbos give me the same benefit will an sglt2 inhibitor give me the same benefit will metformin give me the same benefit”